Yes, you can make money playing 3 card poker. It's a mix of skill and luck. Knowing when to bet and when to fold is crucial. Some people have had good wins, but like any gambling, there are no guarantees.
The best Three Card Poker strategy suggests that you should play all hands better than Queen, Six and Four, then fold all hands with a lesser value. If you fold, your hand is over and the dealer collects your ante wager and pair of plus wager.